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Gold nanoparticles (AuNPs) are tiny particles of gold that range in size from 1 to 100 nanometers and exhibit unique optical, electronic, and chemical properties compared to bulk gold. Their small size and large surface area make them highly reactive and suitable for a wide range of applications, especially in medicine and diagnostics. One of their most notable characteristics is surface plasmon resonance (SPR), which gives them the ability to absorb and scatter light efficiently. This property makes gold nanoparticles ideal for use in imaging techniques, biosensing, and photothermal therapy.
In biomedical fields, gold nanoparticles are widely used for targeted drug delivery, cancer treatment, and as contrast agents in imaging. Their biocompatibility and ability to be easily functionalized with various biomolecules enhance their effectiveness in targeting specific cells or tissues. Additionally, they are employed in environmental monitoring, electronics, and catalysis. Ongoing research continues to expand the potential of gold nanoparticles, particularly in developing more precise and non-invasive diagnostic tools and therapies, making them a valuable component in nanotechnology and modern medicine.
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Membrane chromatography is an advanced purification technique that combines the principles of traditional chromatography with membrane filtration. Instead of using packed resin columns, this method employs membranes functionalized with specific ligands to selectively bind target molecules such as proteins, nucleic acids, or viruses. The flat-sheet or hollow-fiber membranes offer high surface area and allow for rapid mass transfer, making the process significantly faster than conventional column chromatography. It is especially advantageous for processing large biomolecules and is widely used in the biotechnology and pharmaceutical industries for downstream processing.
One of the key benefits of membrane chromatography is its scalability and ease of integration into continuous processing systems. Due to its disposable format, it reduces the need for cleaning and validation, which lowers operational costs and risk of cross-contamination. The technique is particularly effective for polishing steps, such as removing impurities like host cell proteins and DNA during the production of monoclonal antibodies or vaccines. As biomanufacturing moves toward more efficient and flexible processes, membrane chromatography is gaining increased adoption due to its speed, efficiency, and adaptability.
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